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Conferência - Um estudo molecular de um componente da maquinaria bacteriana envolvida na adaptação hiperosmótica

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Data: 28 de Maio

Hora: 12H00
Local: Auditório da Biblioteca
"A molecular study of a component of the bacterial machinery involved in hyperosmotic adaptation", por João Morais Cabral (IBMC, Porto)
Abstract

KtrAB is abacterial K+/Na* transporter that is involved in the first steps of adaptation to hyperosmotic shock. This process involves signaling by ATP/ADP and a change in the conformation of the transporter. I will present the crystal structure of the KtrABATP transporter and will describe biochemical and functional experiments that reveal details of the molecular mechanism of transport activation.

Vieira-Pires RS, Szollosi A, Morais-Cabral JH “The structure of the KtrAB potassium transporter” Nature (2013), 496:323-8

 

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Significant Findings On The Italian Lustred Majolica at Reinassance

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Data: 11 de Junho

Hora: 12:00h
Local: Auditório da Biblioteca da FCT-UNL
The characterization and the study of lustre-decorated majolicas is of great interest for archaeologists, but also offers possibilities for producing pottery with outstanding decoration today, following ancient examples, since nowadays Italian artisans are interested in the reproduction of the ancient recipes and procedures.
The results of several studies carried out on ancient lustre layers using numerous different analytical techniques such as XRD, SEM–EDX, TEM–EDX–SAED, ETAAS, ICP–OES, UV–vis reflectance spectroscopy and SAXS will be presented. Lustre films were shown to be formed by copper and silver clusters of nanometric dimension. The color and the properties of the lustre films depend on the elemental composition of the impasto applied to the ceramic surface as well as on other factors like the metallic nanocluster dimension, the firing conditions, the underlying glaze composition and the procedure. Furthermore, by means of XRD was possible to discover markers, useful in the attribution of works of art to different civilizations.

Giuseppina Padeletti 

(Institute of Nanostructured Materials, CNR, Italy, http://www.ismn.cnr.it/eng/istituto.htm)

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Sistemas cristalográficos: 6, 7 ou infinitos?

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Data: 18 Junho, Quarta-Feira

Hora:12h00
Local: Auditório da Biblioteca FCT UNL
Abstract
Nos seus aspectos mais elementares, a cristalografia geométrica é uma ciência que não
apresenta dificuldades de maior; contudo, o carácter “evidente” de grande parte dos seus conceitos tem o efeito algo perverso de serem geralmente omitidas ou as suas definições ou discussões alargadas das suas implicações. A consequência é, geralmente, esses conceitos acabarem por ser relativamente mal conhecidos.
Um exemplo clássico desta situação é a noção, central em cristalografia geométrica, de sistema cristalográfico. Na generalidade das obras, o conceito é só parcialmente definido e é tratado sistematicamente tendo por base certas características geométricas relativas dos seus eixos que, sendo obviamente relevantes e geralmente suficientes para a maior parte dos usos a que o conceito é posto, não deixam de ser aspectos colaterais, quase extrínsecos, da noção de sistema em si. Não admira, pois, que nunca se tenha chegado a um consenso bem definido sobre quantos são efectivamente os sistemas que se devem
considerar.

Na palestra, tentar-se-á perceber, sempre a nível elementar, o que é efectivamente um sistema cristalográfico, com a esperança de que desse aprofundamento sairá automaticamente quais os sistemas cristalográficos que devem ser usados e portanto, qual o seu número efectivo. Este caminho levar-nos-á a visitar longamente um outro conceito fundamental (e igualmente mal conhecido na sua essência) da Cristalografia geométrica, a simetria, e a investigar qual o seu papel na descrição rigorosa das estruturas cristalinas.

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Neutron and Synchrotron Radiation for Structural (Glyco)-Sciences

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Data: 16 de Junho

Hora: 12h00
Local: Departamento Química FCT-UNL
Abstract
To fully address emerging challenges, scientists must investigate Real materials, in Real conditions and in Real Time. The intricacy of such challenges is far beyond the conventional scientific disciplines (Biology, Chemistry, Physics, Material Science, Geosciences, and imaging) and requires the use of unique large scale facilities that allow scientists to investigate materials at the atomic scale, thus enabling them to perform discoveries that translate into innovations and technology breakthrough. Synchrotron and Neutron sources are more and more used to these ends also facing an increased demand for industrial applications. Compared to conventional laboratory X-rays the spatial resolution and in-depth information achievable can be increased by several orders of magnitude by using synchrotron radiation and neutrons, in there complementarity. The application of neutron radiation is well adapted to the field of organic and bio-macromolecular structures using the Hydrogen-Deuterium effect. It is also well suited to characterize molecular vibrations throughout low-energy spectroscopy, and to the characterization of magnetic structures and excitations. Synchrotron radiation is increasingly applied to macromolecular crystallography and in particular to the elucidation of protein and virus crystal structures. 

Biography
To fully address emerging challenges, scientists must investigate Real materials, in Real conditions and in Real Time. The intricacy of such challenges is far beyond the conventional scientific disciplines (Biology, Chemistry, Physics, Material Science, Geosciences, and imaging) and requires the use of unique large scale facilities that allow scientists to investigate materials at the atomic scale, thus enabling them to perform discoveries that translate into innovations and technology breakthrough.

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Beleza e Fitness por finalidade: a arquitetura das proteínas, os blocos de construção da vida

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Data:23 Junho

Hora:15:00
Local:Auditório da Biblioteca da FCT-UNL
Robert Huber  (Max-Planck Institut für Biochemie Martinsried, Alemanha)

Prémio Nobel da Química 1988

Abstrato
Visualizações atómica de estruturas de proteínas são determinadas com ritmo crescente nos últimos 20 anos por um rápido desenvolvimento de métodos e instrumentos de cristalografia de proteínas, microscopia eletrónica e de ressonância magnética nuclear, permitindo a determinação de estruturas de proteínas muito grandes e complexas. Estas estruturas documentam a beleza e versatilidade ilimitada da arquitetura de proteínas, mas revelam também relações inesperadas, permitindo ver em vários pontos de vista a evolução biológica atrás no tempo. As estruturas são a base para a compreensão específica das proteínas de ligação e propriedades catalíticas (química), os seus espectros e de transferência de eléctrões tal como as suas propriedades (físicas), e os seus papéis em sistemas fisiológicos (biologia e medicina). Eles permitem design e desenvolvimento de ligações específicos de proteínas-alvo de abertura novas estratégias de intervenção terapêutica e desenvolvimento de novos medicamentos e para a proteção das plantas. A partir dos estudos descritos e de biologia molecular, em geral, é de difracção de raios-X de cristais, descoberto por Laue em 1912 em Munique. Celebramos a Laue Centennial, no ano de 2012 e comemorar o Ano Internacional da Cristalografia em 2014. Com alguns slides que deve discutir a história e desenvolvimento da descoberta de Laue, que revolucionou vários campos da ciência.

 

 

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PTNMR coordinated by Prof. Eurico Cabrita was recommended to integrate the National Roadmap of Research Infrastructures

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In the recent FCT call for the National Roadmap for Research Infrastructures the Portuguese Nuclear Magnetic Resonance Network (PTNMR) coordinated by Prof. Eurico Cabrita was recommended to integrate the National Roadmap of Research Infrastructures and was classified as Category 1 - by having demonstrated high scientific potential and being considered to have high strategic regional and/or national relevance.

The PTNMT was considered as a relevant research infrastructure in the context of the European Roadmap of Research Infrastructures, namely by its articulation with the ESFRI - INSTRUCT.

In the recent FCT call for the National Roadmap for Research Infrastructures the Portuguese Nuclear Magnetic Resonance Network (PTNMR) coordinated by Prof. Eurico Cabrita was recommended to integrate the National Roadmap of Research Infrastructures and was classified as Category 1 - by having demonstrated high scientific potential and being considered to have high strategic regional and/or national relevance.

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Professors José Luís Capelo e Carlos Lodeiro, from C40 research group, published a Special Issue on Journal of Proteomics

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Professors José Luís Capelo e Carlos Lodeiro, from C40 research group of UCIBIO in Chemistry Department, had just published a Special Issue on Journal of Proteomics (Elsevier), in collaboration with Professors Marco Aurelio Zezzi Arruda and Carlos Ramos, from Chemistry Institute at Universidade de Campinas in Brasil, about Environmental and structural proteomics.

Professors José Luís Capelo e Carlos Lodeiro, from C40 research group of UCIBIO in Chemistry Department, had just published a Special Issue on Journal of Proteomics (Elsevier), in collaboration with Professors Marco Aurelio Zezzi Arruda and Carlos Ramos, from Chemistry Institute at Universidade de Campinas in Brasil, about Environmental and structural proteomics.

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Prof. Dr. Robert Huber, Nobel Prize for Chemistry in 1988, at FCT-UNL

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Prof. Dr. Robert Huber from Max-Planck-Institut für Biochemie in Germany gave a seminar at the library auditorium, as part of the Cycle of Conferences on Crystallography, within the scope of the International Year of Crystallography. Prof. Dr. Robert Huber visited the laboratories of Chemistry Department during the morning, and researchers had the opportunity to talk to him about their work. 

Prof. Dr. Robert Huber from Max-Planck-Institut für Biochemie in Germany gave a seminar at the library auditorium, as part of the Cycle of Conferences on Crystallography, within the scope of the International Year of Crystallography. Prof. Dr. Robert Huber visited the laboratories of Chemistry Department during the morning, and researchers had the opportunity to talk to him about their work.

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The CrystalSense Solutions team composed by researchers from FCT-UNL will present their project “CrystalSense Solutions - Patterning your Senses” in COHiTEC 2014

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Cecília Roque, head of Biomolecular Engineering Lab, and her team composed by Ana Margarida Dias, Ana Sofia Pina and Ricardo Branco, participated in COHiTEC 2014 program. The program aims to support the valuation of the knowledge produced at Portuguese R&D institutions. Next July 1, the tech-based projects that participated in COHiTEC 2014 will be presented publicly in a Closing Session that will take place at Porto Business School, starting at 2 pm.

Cecília Roque, head of Biomolecular Engineering Lab, and her team composed by Ana Margarida Dias, Ana Sofia Pina and Ricardo Branco, participated in COHiTEC 2014 program. The program aims to support the valuation of the knowledge produced at Portuguese R&D institutions. Next July 1, the tech-based projects that participated in COHiTEC 2014 will be presented publicly in a Closing Session that will take place at Porto Business School, starting at 2 pm.

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Diana Ribeiro awarded with The Best Poster Award by The International Organization for Biological Crystallization

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On June 23rd, Diana Ribeiro, from the Macromolecular Crystallography & GlycoLab Group at FCT-UNL, was awarded the Prize for Best Poster entitled “Use of Gold Nanoparticles as Additives in Protein Crystallization”, by The International Organization for Biological Crystallization, in the 1st FEBS-INSTRUCT Practical Crystallization Course, Advanced Methods in Macromolecular Crystallization VI, that took place in the Academic and University Center at Nové Hrady, Czech Republic. 

 

 

On June 23rd, Diana Ribeiro, from the Macromolecular Crystallography & GlycoLab Group at FCT-UNL, was awarded the Prize for Best Poster entitled “Use of Gold Nanoparticles as Additives in Protein Crystallization”, by The International Organization for Biological Crystallization, in the 1st FEBS-INSTRUCT Practical Crystallization Course, Advanced Methods in Macromolecular Crystallization VI, that took place in the Academic and University Center at Nové Hrady, Czech Republic.

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Professors Carlos Lodeiro and José Luís Capelo publish a special issue of the Dyes and Pigments Journal (Elsevier)

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Professors Carlos Lodeiro and José Luís Capelo from the BIOSCOPE group at Chemistry Department, CEOS of the Proteomass Scientific Association, have just coordinated a Special Issue on the Dyes and Pigments Journal (Elsevier). This special issue brings us the unique occasion to witness the work of leading researches in all branches of the field, including the design of new molecules, new chemosensors/probes, new applications in material science and biosciences and new methods of analysis– says Professor Carlos Lodeiro and Professor José Luís Capelo. Here are collected 28 research articles, from international research groups, that involve the use of Light as an analytical tool.

The special issue is dedicated to 1st IC3EM (1st International Caparica Congress on Chromogenic and Emissive Materials, 2014) that is taking place in Costa da Caparica from 8 to 11 September, bringing together 280 international scientists of the optical fields that are based on light and color as measuring tools. Leading scientists of the field are giving conferences, namely Prof. A. Prasanna De Silva (UK), Prof. Fernando Pina (Portugal), Prof. Ramón Martínez-Mañez (Spain), Prof. Olá Söderberg (Sweden) e Prof. Engin U. Akkaya (Turkey). The scientific program comprises 120 conferences and 90 posters. The Conference Series IC3EM on Chromogenic and Emissive Materials starts this year 2014 in Caparica (Portugal) and aims to take forward the “Caparica” name throughout the world, and link it to Light and Colour.

Professors Carlos Lodeiro and José Luís Capelo from the BIOSCOPE group at Chemistry Department, CEOS of the Proteomass Scientific Association, have just coordinated a Special Issue on the Dyes and Pigments Journal (Elsevier). This special issue brings us the unique occasion to witness the work of leading researches in all branches of the field, including the design of new molecules, new chemosensors/probes, new applications in material science and biosciences and new methods of analysis– says Professor Carlos Lodeiro and Professor José Luís Capelo.

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Cecília Roque’s team developed a technology to rapidly detect the presence of bacteria on a surgical wound

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Crystal Sense, funded by four researchers of UCIBIO at FCT/UNL, is developing a promising product that will reduce the number of infections and its effects, following a surgery. Cecília Roque, head of the Biomolecular Engineering Lab, and mentor of this project, explains that every year, there are around 285 million surgery wounds in the world; it is estimated that there is a probability of infection in 10 % of the surgeries. The problem is that not always these surgical site infections are detected, as their symptoms are often confused with symptoms caused by the surgery itself.  Even when doctors or nurses suspect of these infections, the confirmation is done by laboratory techniques, which takes 24 to 48 hours to reveal which is the microorganism responsible for that infection. The Crystal Sense team, composed by Cecília Roque, Ana Margarida Dias, Ana Sofia Pina and Ricardo Branco, idealize a wound dressing that will detect and alert for the presence of microorganisms on the surgical wound in a few seconds.

Crystal Sense, funded by four researchers of UCIBIO at FCT/UNL, is developing a promising product that will reduce the number of infections and its effects, following a surgery. Cecília Roque, head of the Biomolecular Engineering Lab, and mentor of this project, explains that every year, there are around 285 million surgery wounds in the world; it is estimated that there is a probability of infection in 10 % of the surgeries.

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Kick-off Meeting of the CHImerASE Project

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Today, September 15, is the first meeting of the project “Integrated Platform for de novo Design and Development of a Chimeric Enzyme for high-value chemicals” (CHImerASE) granted by European Research Area (ERA) Industrial Biotechnology. The project involves a translational cooperation between Austria, Germany and Portugal. Cecília Roque, head of the Biomolecular Engineering Lab at UCIBIO - FCT/UNL, is one of the project leaders, together with Vlada B. Urlacher (Germany), Christian Gruber (Austria), Michael Breuer (Germany) and Helmut Schwab (Austria). The project is coordinated by Ricardo Branco, post-doc of the Biomolecular Engineering Lab at UCIBIO - FCT/UNL.

The CHImerASE project started on July, and intends to develop a platform for the design of chimeric enzymes applied to new biotransformation steps. The team aims to deliver an efficient de novo designed enzyme to accomplish a high value industrial transformation that is currently only accessible via a laborious conventional chemical process. The consortium partners strongly believe that such innovative approach will represent a breakthrough in the biocatalysis field with a significant impact at industrial, economical and environmental levels.

Today, September 15, is the first meeting of the project “Integrated Platform for de novo Design and Development of a Chimeric Enzyme for high-value chemicals” (CHImerASE) granted by European Research Area (ERA) Industrial Biotechnology. The project involves a translational cooperation between Austria, Germany and Portugal. Cecília Roque, head of theBiomolecular Engineering Lab at UCIBIO - FCT/UNL, is one of the project leaders, together with Vlada B.

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Bolsa de Mérito do DQ para o melhor aluno do 1º ano das Licenciaturas em Química Aplicada, em Bioquímica e Mestrado Integrado em Engª Química e Bioquímica

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O DQ iniciou este ano a atribuição de uma Bolsa de Mérito ao melhor aluno de Licenciatura que se encontra no 2º ano (o aluno que terminou o 1.º ano das LQA, LBioq ou MIEQB com a melhor classificação).

O vencedor foi o aluno  Bruno Filipe Pinto Branco, aluno do 2º ano do MIEQB, que terminou o 1º ano com a média de 17,85 valores.

Esta bolsa tem o valor de cerca de 1300 €. O estudante que recebe a bolsa, paga a propina mínima em vez da propina anual, durante 3 anos consecutivos.

 

 

O DQ iniciou este ano a atribuição de uma Bolsa de Mérito ao melhor aluno de Licenciatura que se encontra no 2º ano (o aluno que terminou o 1.º ano das LQA, LBioq ou MIEQB com a melhor classificação).

O vencedor foi o aluno  Bruno Filipe Pinto Branco, aluno do 2º ano do MIEQB, que terminou o 1º ano com a média de 17,85 valores.

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Professor Carlos Lodeiro distinguido com o estatuto de Fellow pela Royal Society of Chemistry de Londres

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Professor Carlos Lodeiro, do grupo Bioscope na unidade UCIBIO do Departamento de Química - FCT / UNL, foi distinguido com o estatuto de Fellow pela Royal Society of Chemistry de Londres. 

Professor Carlos Lodeiro, do grupo Bioscope na unidade UCIBIO do Departamento de Química - FCT / UNL, foi distinguido com o estatuto de Fellow pela Royal Society of Chemistry de Londres.

Os Fellows são eleitos através de um processo de revisão por pares com base na avaliação do Curriculum Vitae para análise de actividades científicas e académicas, que culmina na votação pelos Fellows existentes. Em breve a nomeação dos novos Fellows será publicada no prestigioso jornal The Times (London).


Research developed by the Bioscope group opens new perspectives for biomedicine

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Collaboration work between the Bioscope group, co-leaded by Professors Carlos Lodeiro e José-Luís Capelo, and the Núcleo de Apoio à Pesquisa (NAP; Centre for Support to Research) Catalysis and Chemical Synthesis of the Universidade de São Paulo (USP), has been very productive regarding new applications of science in medicine.

Collaboration work between the Bioscope group, co-leaded by Professors Carlos Lodeiro e José-Luís Capelo, and the Núcleo de Apoio à Pesquisa (NAP; Centre for Support to Research) Catalysis and Chemical Synthesis of the Universidade de São Paulo (USP), has been very productive regarding new applications of science in medicine.

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NOVA chemistry in international ranking

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NOVA university featured in QS World University Rankings
 

As widely publicized by the national press, the Universidade NOVA de Lisboa was the only Portuguese University featured in the QS Top 50 Under 50, an international ranking of the top 50 young universities in the world, having been placed in the 36th position. This ranking highlights the world’s top 50 universities established within the last 50 years, based on several criteria to assess performance, including academic reputation, reputation among employers, and internationalization.

As widely publicized by the national press, the Universidade NOVA de Lisboa was the only Portuguese University featured in the QS Top 50 Under 50, an international ranking of the top 50 young universities in the world, having been placed in the 36th position.

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Filipa Marcelo’s findings open up new possibilities for the development of new cancer vaccines

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An important finding has been published today in Chemistry - A European Journal by Filipa Marcelo, from the Bio-NMR group at UCIBIO in Lisbon, led by Eurico Cabrita, professor at the Chemistry Department at FCT-UNL. The paper was recommended as a Very Important Paper by the Journal, according to the excellent evaluation of the referees. 

An important finding has been published today in Chemistry - A European Journal by Filipa Marcelo, from the Bio-NMR group at UCIBIO in Lisbon, led by Eurico Cabrita, professor at the Chemistry Department at FCT-UNL. The paper was recommended as a Very Important Paper by the Journal, according to the excellent evaluation of the referees.

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Professor José Luis Capelo Martínez distinguido como "Fellow" pela Royal Society of Chemistry

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Professor J. L. Capelo, do grupo Bioscope na unidade UCIBIO do Departamento de Química - FCT / UNL, foi distinguido com o estatuto de Fellow pela Royal Society of Chemistry, RSC, de Londres. Os Fellows da RSC são eleitos através de um processo de revisão por pares com base na avaliação do Curriculum Vitae para análise de actividades científicas e académicas, que culmina na votação pelos pares Fellows existentes. Em breve a nomeação dos novos Fellows será publicada no prestigiado jornal The Times (London).

Professor J. L. Capelo, do grupo Bioscope na unidade UCIBIO do Departamento de Química - FCT / UNL, foi distinguido com o estatuto de Fellow pela Royal Society of Chemistry, RSC, de Londres. Os Fellows da RSC são eleitos através de um processo de revisão por pares com base na avaliação do Curriculum Vitae para análise de actividades científicas e académicas, que culmina na votação pelos pares Fellows existentes.

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Carlos Lodeiro e José Luis Capelo publicam um Special Issue do Journal of Nanoparticle Research da Springer

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Carlos Lodeiro e José Luís Capelo do grupo BIOSCOPE na UCIBIO, CEOS da Associação Científica PROTEOMASS, acabam de coordenar a edição de um número tópico especial do “Journal of Nanoparticle Research” da Editorial Springer onde se reunem vários trabalhos internacionais envolvendo a síntese e aplicações de Composite Nanoparticles. 

Carlos Lodeiro e José Luís Capelo do grupo BIOSCOPE, Professores no Departamento de Química e CEOS da Associação Científica PROTEOMASS, acabam de coordenar a edição de um número tópico especial do “Journal of Nanoparticle Research” da Editorial Springer onde se reunem vários trabalhos internacionais envolvendo a síntese e aplicações de Composite Nanoparticles.

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